complex coenzyme
2-Amino-6-purinethiol
CAS: 154-42-7
Molecular Formula: C5H5N5S
complex coenzyme - Names and Identifiers
complex coenzyme - Physico-chemical Properties
| Molecular Formula | C5H5N5S |
| Molar Mass | 167.19 |
| Density | 1.483 (estimate) |
| Melting Point | ≥300°C(lit.) |
| Boling Point | 555.4±42.0 °C(Predicted) |
| Flash Point | 356°C |
| Water Solubility | soluble |
| Solubility | Practically insoluble in water and in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides. |
| Vapor Presure | 1.5E-17mmHg at 25°C |
| Appearance | odorless or nearly odorless pale yellow crystalline powder |
| Color | Yellow to green |
| Merck | 14,9337 |
| BRN | 157765 |
| pKa | pKa 8.22 (Uncertain) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMF may be stored at -20°C for up to 1 month. |
| Refractive Index | 1.5605 (estimate) |
| MDL | MFCD00233553 |
| Physical and Chemical Properties | White or yellowish powder, umami, soluble in water, difficult to dissolve in ethanol, acetone and other organic solvents. |
| Use | Anti-tumor. |
complex coenzyme - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UP0740000 |
| FLUKA BRAND F CODES | 13 |
| HS Code | 29335990 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 oral in mouse: 160mg/kg |
complex coenzyme - Reference
| Reference Show more | 1. Hou, Changsheng, et al. "Effect of 6‐thioguanine, as an electrolyte additive, on the electrochemical behavior of an Al–air battery." Materials and Corrosion 71.9 (2020): 1480-1487.https://doi.org/10.1002/maco.202011542 |
complex coenzyme - Nature
Open Data Verified Data
- This product is light yellow crystalline powder; Odorless or almost odorless. Insoluble in water, ethanol or chloroform; Soluble in dilute sodium hydroxide solution.
- This product is purine Antimetabolite. After being converted into the corresponding nucleotides in vivo, it can inhibit the synthesis of purine nucleotides; Its metabolic pathway is similar to that of mercaptopurine, which is a kind of DNA base, it can be incorporated into a DNA molecule as a wrong base, thus affecting the synthesis and function of DNA. It mainly acts on S phase, is a cycle specific drug, and has cross resistance to mercaptopurine, but the toxicity is small. In vivo metabolic pathways are: after methylation to become 2-amino -6-thiopurine, after the amino group to become 2-hydroxy -6-mercaptopurine, part of the oxidation to thiouric acid form is excreted in the urine.
Last Update：2024-01-02 23:10:35
complex coenzyme - Preparation Method
Open Data Verified Data
prepared from guanine by substitution reaction of diphosphorus pentasulfide in the presence of ammonium hydroxide with pyridine.
Last Update：2022-01-01 11:12:25
complex coenzyme - Introduction
Soluble in NaOH solution.
Last Update：2022-10-16 17:14:08
complex coenzyme - Application
Open Data Verified Data
- Anti-tumor drug. For the treatment of various types of leukemia, acute leukemia is more commonly used.
- usage and dosage in combination with cytarabine, daunorubicin and prednisone have good curative effect on adult acute non-lymphocytic leukemia. Oral, 2~2.5 mg per kilogram of body weight per day, once or divided, 5~7 days for a course of treatment.
- light shielding, sealed storage.
Last Update：2025-08-19 16:24:40
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Product Name: 6-Thioguanine Request for quotationCAS: 154-42-7
Tel: 400-968-2212
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Wechat: 18916960931
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Product Name: 6-Thioguanine Visit Supplier Webpage Request for quotationCAS: 154-42-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: 6-Thioguanine (Standard) Visit Supplier Webpage Request for quotationCAS: 154-42-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 6-Thioguanine Visit Supplier Webpage Request for quotationCAS: 154-42-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: 6-Thioguanine Visit Supplier Webpage Request for quotationCAS: 154-42-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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